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Review
. 2012 Aug;14(9):672-83.
doi: 10.1016/j.micinf.2012.02.002. Epub 2012 Feb 24.

BK polyomavirus: emerging pathogen

Shauna M Bennett  1 , Nicole M Broekema, Michael J Imperiale
Affiliations
Review

BK polyomavirus: emerging pathogen

Shauna M Bennett et al. Microbes Infect. 2012 Aug.

Abstract

BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging pathogen in immunocompromised individuals. BKPyV is widespread in the general population, but primarily causes disease when immune suppression leads to reactivation of latent virus. Polyomavirus-associated nephropathy and hemorrhagic cystitis in renal and bone marrow transplant patients, respectively, are the most common diseases associated with BKPyV reactivation and lytic infection. In this review, we discuss the clinical relevance, effects on the host, virus life cycle, and current treatment protocols.

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