Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Mar;86(3):470-3.
doi: 10.4269/ajtmh.2012.11-0295.

Unifocal bone paracoccidioidomycosis, Brazil

Bruna Correa-de-Castro  1 , Mauricio A Pompilio, Danilo N Odashiro, Maçanori Odashiro, Adalberto Arão-Filho, Anamaria M M Paniago
Affiliations
Case Reports

Unifocal bone paracoccidioidomycosis, Brazil

Bruna Correa-de-Castro et al. Am J Trop Med Hyg. 2012 Mar.

Abstract

We report a 47 year-old man from the State of Mato Grosso do Sul, Brazil, with unifocal tibial paracoccidioidomycosis. A radiograph showed an osteolytic lesion on the tibial middle third diaphysis. The diagnosis was confirmed by histopathologic analysis, and treatment with sulfamethoxazole and trimethoprim was started. After three months, the patient showed significant clinical improvement. Ten months after treatment, the patient showed lesion bone healing. This case describes the rare occurrence of an osteolytic lesion caused by endemic Paracoccidioides brasiliensis in Latin America.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
A, Pre-treatment radiograph of the patient showing an oval osteolytic lesion on the left tibia. B, Radiograph after five months of treatment showing partial bone healing. C, Radiograph after 10 months of treatment showing consolidation of the bone injury.
Figure 2.
Figure 2.
Histologic examination of bone lesion of the patient showing Paracoccidioides brasiliensis yeast (arrows). A, Hematoxylin and eosin stained (magnification×400). B, Grocott stained (magnification×400).
Figure 3.
Figure 3.
Chest radiograph of the patient showing no evidence of pulmonary involvement.
Figure 4.
Figure 4.
Technetium-99m methylene diphosphonate scintigraphy of the patient. A, Physiologic radiopharmaceutical distribution with uptake in the middle third of left tibia (arrow). B, Equilibrium phase. C, Late phase.
See this image and copyright information in PMC

References

    1. Picado CH, Garcia FL, Marcondes CR. Late outcome of Paracoccidioides brasiliensis isolated infection on the hip. Acta Ortop Bras. 2006;24:97–99.
    1. Silvestre MT, Ferreira MS, Borges AS, Rocha A, De Souza GM, Nishioka SA. Monoartrite de joelho como manifestação isolada de paracoccidioidomicose. Rev Soc Bras Med Trop. 1997;30:393–395. - PubMed
    1. David A, Telóken MA, Dalmina V, Oliveira GK, Oliveira RK. Bone paracoccidioidomycosis: report of a case. Rev Bras Ortop. 1997;32:254–256.
    1. Nogueira MGS Andrade GM, Tonelli E. Clinical evolution of paracoccidioidomycosis in 38 children and teenagers. Mycopathologia. 2006;161:73–81. - PubMed
    1. Blotta MH, Mamoni RL, Oliveira SJ, Nouer SA, Papaiordanou PM, Goveia A, Camargo ZP. Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. Am J Trop Med Hyg. 1999;61:390–394. - PubMed

Publication types