Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012 Mar;86(3):486-8.
doi: 10.4269/ajtmh.2012.11-0476.

Efficacy of a single oral dose of oxfendazole against Fasciola hepatica in naturally infected sheep

Luis A Gomez-Puerta  1 , Cesar Gavidia, Maria T Lopez-Urbina, Hector H Garcia, Armando E Gonzalez; Cysticercosis Working Group in Peru
Affiliations
Randomized Controlled Trial

Efficacy of a single oral dose of oxfendazole against Fasciola hepatica in naturally infected sheep

Luis A Gomez-Puerta et al. Am J Trop Med Hyg. 2012 Mar.

Abstract

The efficacy of a single oral dose of 30 mg/kg of oxfendazole against Fasciola hepatica was evaluated in a controlled study in naturally infected sheep. Sheep were diagnosed by stool microscopy after sedimentation, and positive animals were randomized to oxfendazole (N = 20) or no treatment (N = 20). A new stool exam was performed 10 days after treatment. All stool microscopies were performed masked to the treatment group. No side effects were noticed. All sheep in the control group remained infected with similar counts of eggs per gram of stools. None of the animals in the treatment group showed Fasciola eggs in stools after 10 days of treatment. A single dose of oxfendazole is highly effective against F. hepatica, providing a new drug alternative for the control of fascioliasis or integrated zoonosis control.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mas-Coma S, Valero MA, Bargues MD. Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. Adv Parasitol. 2009;69:41–146. - PubMed
    1. Lean I, Westwood C, Playford M. Livestock disease threats associated with intensification of pastoral dairy farming. N Z Vet J. 2008;56:261–269. - PubMed
    1. Parkinson M, O’Neill SM, Dalton JP. Endemic human fasciolosis in the Bolivian Altiplano. Epidemiol Infect. 2007;135:669–674. - PMC - PubMed
    1. Marcos LA, Terashima A, Leguia G, Canales M, Espinoza JR, Gotuzzo E. Fasciola hepatica infection in Peru: an emergent disease. Rev Gastroenterol Peru. 2007;27:389–396. - PubMed
    1. Espinoza JR, Terashima A, Herrera-Velit P, Marcos LA. Human and animal fascioliasis in Peru: impact in the economy of endemic zones. Rev Peru Med Exp Salud Publica. 2010;27:604–612. - PubMed

Publication types

LinkOut - more resources