Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Mar 11:11:6.
doi: 10.1186/1476-0711-11-6.

Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant Staphylococcus aureus in a renal transplant recipient with Fabry-Anderson disease

Ennio Polilli  1 , Tamara Ursini, Elena Mazzotta, Federica Sozio, Vincenzo Savini, Domenico D'Antonio, Michelino Barbato, Augusta Consorte, Giustino Parruti
Affiliations
Case Reports

Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant Staphylococcus aureus in a renal transplant recipient with Fabry-Anderson disease

Ennio Polilli et al. Ann Clin Microbiol Antimicrob. .

Abstract

Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to first-line Teicoplanin and second-line Tigecycline, whereas he was successfully treated with third-line Daptomycin monotherapy at 4 mg/Kg/qd for 4 weeks. Local debridement was performed in advance of each line of treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
a) Ulcerative lesion of the right heel; b) Standard Rx scan of the right heel at patient entry.
Figure 2
Figure 2
Standard Rx scan of the right heel at end of treatment.
See this image and copyright information in PMC

References

    1. Deresinski S. Counterpoint: vancomycin and staphylococcus aureus--an antibiotic enters obsolescence. Clin Infect Dis. 2007;44:1543–1548. doi: 10.1086/518452. - DOI - PubMed
    1. Allison DC, Holtom PD, Patzakis MJ, Zalavras CG. Microbiology of bone and joint infections in injecting drug abusers. Clin Orthop Relat Res. 2010;468:2107–2112. doi: 10.1007/s11999-010-1271-2. - DOI - PMC - PubMed
    1. Brook I. Microbiology and management of joint and bone infections due to anaerobic bacteria. J Orthop Sci. 2008;13:160–169. doi: 10.1007/s00776-007-1207-1. - DOI - PubMed
    1. Lipsky BA, Weigelt JA, Gupta V, Killian A, Peng MM. Skin, soft tissue, bone, and joint infections in hospitalized patients: epidemiology and microbiological, clinical, and economic outcomes. Infect Control Hosp Epidemiol. 2007;28:1290–1298. doi: 10.1086/520743. - DOI - PubMed
    1. Mader JT, Mohan D, Calhoun J. A practical guide to the diagnosis and management of bone and joint infections. Drugs. 1997;54:253–264. doi: 10.2165/00003495-199754020-00004. - DOI - PubMed

Publication types

MeSH terms