Supersizing the mitochondrial respiratory chain
- PMID: 22405063
- DOI: 10.1016/j.cmet.2012.02.009
Supersizing the mitochondrial respiratory chain
Abstract
The complexes of the mitochondrial respiratory chain assemble into higher-order structures called supercomplexes or respirasomes that are thought to be important in channeling electron flow and controlling ROS production. A number of recent papers identify the first protein factors necessary for supercomplex assembly and stability.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Mitochondrial complex I plays an essential role in human respirasome assembly.Cell Metab. 2012 Mar 7;15(3):324-35. doi: 10.1016/j.cmet.2012.01.015. Epub 2012 Feb 16. Cell Metab. 2012. PMID: 22342700 Free PMC article.
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Identification of a protein mediating respiratory supercomplex stability.Cell Metab. 2012 Mar 7;15(3):348-60. doi: 10.1016/j.cmet.2012.02.006. Cell Metab. 2012. PMID: 22405070 Free PMC article.
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