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Review
. 2012 Mar 7;15(3):292-7.
doi: 10.1016/j.cmet.2012.02.004.

Modulation of leptin resistance by protein tyrosine phosphatases

Julie St-Pierre  1 , Michel L Tremblay
Affiliations
Free article
Review

Modulation of leptin resistance by protein tyrosine phosphatases

Julie St-Pierre et al. Cell Metab. .
Free article

Abstract

Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling.

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