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Comment
. 2012 Mar 9;45(5):585-6.
doi: 10.1016/j.molcel.2012.02.011.

Keeping it together in times of stress: checkpoint function at stalled replication forks

Theresa J Berens  1 , David P Toczyski
Affiliations
Comment

Keeping it together in times of stress: checkpoint function at stalled replication forks

Theresa J Berens et al. Mol Cell. .

Abstract

In this issue of Molecular Cell, De Piccoli et al. (2012) show that, contrary to current models of DNA replication checkpoint function, replication proteins remain associated with each other and with replicating DNA when replication is stressed in checkpoint-deficient cells.

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Figures

None
Previously-proposed models for how replication forks collapse in checkpoint-deficient mutants upon HU treatment
(A) A replication fork in the absence of replication stress. (B) The helicase proceeds without the polymerases. (C) The replisome translocates intact, but the polymerases have disengaged. (D) The replisome dissociates from chromatin.
See this image and copyright information in PMC

Comment on

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