Review
BRCA and pancreatic cancer: selection of chemotherapy
Affiliations
- PMID: 22406596
Item in Clipboard
Review
BRCA and pancreatic cancer: selection of chemotherapy
JOP.
.
Free article
Abstract
Germline mutations in BRCA genes are associated with increased risk of pancreatic cancer. There are pre clinical data which suggests that DNA cross linking agents should be used in pancreatic cancer patients with BRCA mutations. This review is an update from the 2012 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium regarding recent developments in the treatment of pancreatic cancer with BRCA mutation. Only one study (Abstracts #217) was presented and it is described here.
Similar articles
-
BRCA and pancreatic cancer.JOP. 2013 Jul 10;14(4):325-8. doi: 10.6092/1590-8577/1652. JOP. 2013. PMID: 23846919 Review.
-
BRCA-associated pancreatic cancer: the evolving management.JOP. 2013 Mar 10;14(2):149-51. doi: 10.6092/1590-8577/1462. JOP. 2013. PMID: 23474559 Review.
-
Pharmacogenetics and other molecular targets in the management of pancreatic adenocarcinoma. Highlights from the "2010 ASCO Annual Meeting". Chicago, IL, USA. June 4-8, 2010.JOP. 2010 Jul 5;11(4):328-30. JOP. 2010. PMID: 20601804 Review.
-
Biomarkers and pharmacogenetics in pancreatic cancer. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011.JOP. 2011 Jul 8;12(4):325-9. JOP. 2011. PMID: 21737888 Review.
-
A 67-year-old woman with BRCA 1 mutation associated with pancreatic adenocarcinoma.J Gastrointest Cancer. 2011 Sep;42(3):160-4. doi: 10.1007/s12029-010-9197-1. J Gastrointest Cancer. 2011. PMID: 20711688
Cited by
-
Germline mutations in pancreatic cancer and potential new therapeutic options.Oncotarget. 2017 Apr 20;8(42):73240-73257. doi: 10.18632/oncotarget.17291. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069866 Free PMC article. Review.
-
The complexities of epidemiology and prevention of gastrointestinal cancers.Int J Mol Sci. 2012 Oct 1;13(10):12556-72. doi: 10.3390/ijms131012556. Int J Mol Sci. 2012. PMID: 23202913 Free PMC article. Review.
-
Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts.Pancreas. 2018 Sep;47(8):924-936. doi: 10.1097/MPA.0000000000001136. Pancreas. 2018. PMID: 30113427 Free PMC article.
-
Ampulla of vater adenocarcinoma in a BRCA2 germline mutation carrier.J Gastrointest Cancer. 2014 Mar;45(1):87-90. doi: 10.1007/s12029-013-9479-5. J Gastrointest Cancer. 2014. PMID: 23417715 No abstract available.
-
Pancreatic cancer patients with germline BRCA mutations can benefit from olaparib treatment.Transl Cancer Res. 2020 Apr;9(4):2154-2156. doi: 10.21037/tcr.2020.03.07. Transl Cancer Res. 2020. PMID: 35117572 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
