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Review
. 2013 Jan;17(1):284-97.
doi: 10.1007/s10461-012-0172-7.

A proposal for quality standards for measuring medication adherence in research

Ann Bartley Williams  1 , K Rivet Amico, Carol Bova, Julie A Womack
Affiliations
Review

A proposal for quality standards for measuring medication adherence in research

Ann Bartley Williams et al. AIDS Behav. 2013 Jan.

Abstract

A decade after widespread recognition that adherence to medication regimens is key to antiretroviral effectiveness, considerable controversy remains regarding a "gold standard" for adherence measurement. Each adherence measurement approach has strengths and weaknesses and each rests on specific assumptions. The range of assumptions regarding adherence measurement and the diversity with which each approach is implemented strongly suggest that the evaluation of a particular measure outside of the context in which it was used (e.g. the study's operational protocol) may result in undeserved confidence or lack of confidence in study results. The purpose of this paper is to propose a set of best practices across commonly used measurement methods. Recommendations regarding what information should be included in published reports regarding how adherence was measured are provided to promote improvement in the quality of measurement of medication adherence in research.

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References

    1. Katzenstein DA, Lyons C, Molaghan JP, Ungvarski P, Wolfe GS, Williams A. HIV therapeutics: confronting adherence. J Assoc Nurses AIDS Care. 1997;8 (Suppl):46–58. - PubMed
    1. Williams A, Friedland G. Adherence, compliance, and HAART. AIDS Clin Care. 1997;9(7):51–4. 8. - PubMed
    1. Wainberg MA, Friedland G. Public health implications of antiretroviral therapy and HIV drug resistance. JAMA. 1998;279(24):1977–83. - PubMed
    1. Haubrich RH, Little SJ, Currier JS, Forthal DN, Kemper CA, Beall GN, et al. The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response. AIDS. 1999;13(9):1099–107. - PubMed
    1. Chesney MA, Ickovics J, Hecht FM, Sikipa G, Rabkin J. Adherence: a necessity for successful HIV combination therapy. AIDS. 1999;13(Suppl A):S271–8. - PubMed

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