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Review
. 2012 May 15;318(9):1049-56.
doi: 10.1016/j.yexcr.2012.02.023. Epub 2012 Mar 3.

Recent advances involving the renin-angiotensin system

Steven D Crowley  1 , Thomas M Coffman
Affiliations
Review

Recent advances involving the renin-angiotensin system

Steven D Crowley et al. Exp Cell Res. .

Abstract

The renin-angiotensin system (RAS) exercises fundamental control over sodium and water handling in the kidney. Accordingly, dysregulation of the RAS leads to blood pressure elevation with ensuing renal and cardiovascular damage. Recent studies have revealed that the RAS hormonal cascade is more complex than initially posited with multiple enzymes, effector molecules, and receptors that coordinately regulate the effects of the RAS on the kidney and vasculature. Moreover, recently identified tissue-specific RAS components have pleomorphic effects independent of the circulating RAS that influence critical homeostatic mechanisms including the immune response and fetal development. Further characterization of the diverse interactions between the RAS and other signaling pathways within specific tissues should lead to novel treatments for renal and cardiovascular disease.

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Figures

Fig. 1
Fig. 1
Schematic of the renin–angiotensin system.
See this image and copyright information in PMC

References

    1. Benigni A., Corna D., Zoja C., Sonzogni A., Latini R., Salio M., Conti S., Rottoli D., Longaretti L., Cassis P., Morigi M., Coffman T.M., Remuzzi G. Disruption of the Ang II type 1 receptor promotes longevity in mice. J. Clin. Invest. 2009;119:524–530. - PMC - PubMed
    1. Husain A., Graham R. Harwood Academic; Sydney: 2000. Drugs, Enzymes and Receptors of the Renin–Angiotensin System: Celebrating a Century of Discovery.
    1. The SOLVD Investigators Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N. Engl. J. Med. 1991;325:293–302. - PubMed
    1. The SOLVD Investigators Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N. Engl. J. Med. 1992;327:725–727. - PubMed
    1. Lewis E.J., Hunsicker L.G., Bain R.P., Rohde R.D. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N. Engl. J. Med. 1993;329:1456–1462. - PubMed