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. 2012 Apr 3;24(13):1742-7.
doi: 10.1002/adma.201104330. Epub 2012 Mar 13.

Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies

Esther Vázquez  1 , José L Corchero, Joan F Burgueño, Joaquin Seras-Franzoso, Ana Kosoy, Ramon Bosser, Rosa Mendoza, Joan Marc Martínez-Láinez, Ursula Rinas, Ester Fernández, Luis Ruiz-Avila, Elena García-Fruitós, Antonio Villaverde
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Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies

Esther Vázquez et al. Adv Mater. .

Abstract

Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.

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