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Case Reports
. 1990;33(2):88-91.

12q13 fragility in a family with recurrent spontaneous abortions: expression of the fragile site under different culture conditions

D Giardino  1 , D Bettio, G Simoni
Affiliations
  • PMID: 2241090
Case Reports

12q13 fragility in a family with recurrent spontaneous abortions: expression of the fragile site under different culture conditions

D Giardino et al. Ann Genet. 1990.

Abstract

A fragile site at the 12q13 band was found in metaphases from lymphocyte cultures of three members of a family. A comparison of the frequency and expression of the fragile site was carried out on cells cultured in RPM-I 1640 with and without BrdU and in 199 media. The fragile site was not typically folate-sensitive, being expressed in standard medium as well as in cultures after exposure to BrdU.

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