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Case Reports
. 2012 Apr;14(4):257-61.
doi: 10.1177/1098612X11435612. Epub 2012 Jan 11.

Interaction of clarithromycin with cyclosporine in cats: pharmacokinetic study and case report

Masaaki Katayama  1 , Noriko Nishijima, Yasuhiko Okamura, Rieko Katayama, Testuro Yamashita, Hiroaki Kamishina, Yuji Uzuka
Affiliations
Case Reports

Interaction of clarithromycin with cyclosporine in cats: pharmacokinetic study and case report

Masaaki Katayama et al. J Feline Med Surg. 2012 Apr.

Abstract

Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough levels in human transplant patients. However, the interaction of CLM with CsA has not been reported in cats. In this study, the effects of oral dosing of CLM on the pharmacokinetics and dosing of CsA in cats were investigated. Co-administration of CLM with CsA resulted in significant increases of oral bioavailability of CsA. In addition, CLM reduced the CsA dosage required to maintain the therapeutic CsA trough levels to almost 35% of the initial CsA therapy and the dose frequency was successfully replaced from a twice a day schedule to once a day in a feline kidney transplant patient. The addition of CLM to the regular CsA-based immunosuppression could be used as an effective alternative to classical ketoconazole treatment in feline kidney transplant patients and may result in substantial cost saving and convenience for the cat owners.

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Conflict of interest statement

The authors do not have any potential conflicts of interest to declare.

Figures

Figure 1
Figure 1
Mean cyclosporine (CsA) blood concentration-time curves of the four healthy cats following treatment A (CsA alone) and treatment B (CsA + single therapeutic dose of clarithromycin (CLM)). In this study, the dosages of CsA and CLM were adjusted to 5 mg/kg and approximately 10 mg/kg (range; 7.96–11.11 mg/kg according to the capsule strength and cat’s weight) respectively
Figure 2
Figure 2
Time courses of cyclosporine (CsA) trough concentrations and dosage after clarithromycin (CLM) treatment in a feline kidney transplant patient
See this image and copyright information in PMC

References

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