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Review
. 2013 Jan;280(2):505-24.
doi: 10.1111/j.1742-4658.2012.08565.x. Epub 2012 Apr 10.

Molecular mechanisms of the PRL phosphatases

Pablo Rios  1 , Xun Li, Maja Köhn
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Free article
Review

Molecular mechanisms of the PRL phosphatases

Pablo Rios et al. FEBS J. 2013 Jan.
Free article

Abstract

The phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver, compare them to related phosphatases, and review recent reports about each phosphatase. Finally, we discuss similarities and differences between the phosphatases of regenerating liver, focusing on their molecular mechanisms and signalling pathways.

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