Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jun;37(7):1764-72.
doi: 10.1038/npp.2012.23. Epub 2012 Mar 14.

Frontal theta cordance predicts 6-month antidepressant response to subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study

James M Broadway  1 , Paul E Holtzheimer, Matthew R Hilimire, Nathan A Parks, Jordan E Devylder, Helen S Mayberg, Paul M Corballis
Affiliations

Frontal theta cordance predicts 6-month antidepressant response to subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study

James M Broadway et al. Neuropsychopharmacology. 2012 Jun.

Abstract

Deep brain stimulation (DBS) of subcallosal cingulate white matter (SCC) may be an effective approach for treatment-resistant depression (TRD) that otherwise fails to respond to more conventional therapies, but DBS is invasive, costly, and has potential for adverse effects. Therefore, it is important to identify potential biomarkers for predicting antidepressant response before intervention. Resting-state EEG was recorded from 12 TRD patients at pre-treatment baseline, after 4 weeks SCC DBS, and after 24 weeks SCC DBS. Lower frontal theta cordance (FTC) at baseline (and higher FTC after 4 weeks) predicted lower depression severity scores after 24 weeks. Greater FTC increases (baseline-4 weeks) predicted greater decreases in depression severity scores subsequently (4-24 weeks) and over the course of the study (baseline-24 weeks). Predictive relationships were topographically specific to theta cordance for frontal electrodes. Thus, results from this pilot study suggest that baseline FTC and changes early in treatment each have utility as biomarkers for predicting 6-month clinical response to SCC DBS for TRD.

PubMed Disclaimer

References

    1. Asada H, Fukuda Y, Tsunoda S, Yamaguchi M, Tonoike M. Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans. Neurosci Lett. 1999;274:29–32. - PubMed
    1. Bares M, Brunovsky M, Kopecek M, Novak T, Stopkova P, Sos P, et al. Early reduction in prefrontal theta QEEG cordance value predicts response to venlafaxine treatment in patients with resistant depressive disorder. Eur Psychiatry. 2008;23:350–355. - PubMed
    1. Bares M, Brunovsky M, Novak T, Kopacek M, Stopkova P, Sos P, et al. The change of prefrontal QEEG theta cordance as a predictor of response to buprion treatment in patients who had failed to respond to previous antidepressant treatments. Eur Neuropsychopharmacol. 2010;20:459–466. - PubMed
    1. Bares M, Novak T, Brunovsky M, Kopacek M, Stopkova P, Krajca V, et al. The change of QEEG prefrontal cordance as a response predictor to antidepressive intervention in bipolar depression. A pilot study. J Psychiatr Res. 2012;46:219–225. - PubMed
    1. Bewernick BH, Hurlemann R, Matusch A, Kayser S, Grubert C, Hadrysiewicz B, et al. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biol Psychiatry. 2010;67:110–116. - PubMed

Publication types

Substances