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Review
. 2012 Jun;9(2):160-70.
doi: 10.1007/s11904-012-0114-z.

HIV-1 prevention for HIV-1 serodiscordant couples

Kathryn Curran  1 , Jared M Baeten, Thomas J Coates, Ann Kurth, Nelly R Mugo, Connie Celum
Affiliations
Review

HIV-1 prevention for HIV-1 serodiscordant couples

Kathryn Curran et al. Curr HIV/AIDS Rep. 2012 Jun.

Abstract

A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother-to-child transmission for HIV-1-infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.

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Figures

Figure 1
Figure 1
Couples HIV testing and counseling topics [18]
See this image and copyright information in PMC

References

    1. UNAIDS [December 14, 2011];Global Report: UNAIDS Report on the Global AIDS Epidemic. 2010 Available at http://www.unaids.org/globalreport/Global_report.htm.
    1. Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505. [This is the first randomized clinical trial to demonstrate that early initiation of ART (between CD4 350-550 cells/mL) signicifanctly reduces the likelhoood of transmitting HIV-1 to sexual partners. HIV-1 serodiscordant couples initiating ART early had 96% fewer HIV-1 infections and had lower incidence of tuberculosis.] - PMC - PubMed
    1. Baeten J, Celum C, The Partners PrEP Study Team Antiretroviral pre-exposure prophylaxis for HIV-1 prevention among heterosexual African men and women: The Partners PrEP Study.. Presented at the VI International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; Rome, Italy. July 17-20, 2011; [This randomized clinical trial demonstrated high efficacy of daily oral PrEP in preventing HIV-1 transmission in HIV-1 serodiscordant couples in sub-Saharan Africa: 62% with tenofovir and 73% with emtricitabine/tenofovir.]
    1. Anand A, Shiraishi RW, Bunnell RE, et al. Knowledge of HIV status, sexual risk behaviors and contraceptive need among people living with HIV in Kenya and Malawi. AIDS. 2009;23(12):1565–73. - PubMed
    1. De Walque D. Sero-discordant couples in five African countries: Implications for prevention strategies. Popul Dev Rev. 2007;33(3):501–523.

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