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. 2012 Apr 15;205(8):1220-4.
doi: 10.1093/infdis/jis178. Epub 2012 Mar 13.

Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008-2010

Sophie Octavia  1 , Vitali Sintchenko, Gwendolyn L Gilbert, Andrew Lawrence, Anthony D Keil, Geoff Hogg, Ruiting Lan
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Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008-2010

Sophie Octavia et al. J Infect Dis. .

Abstract

Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.

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