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Review
. 2012 Mar 15;12(4):298-306.
doi: 10.1038/nrc3245.

The immune contexture in human tumours: impact on clinical outcome

Wolf Herman Fridman  1 , Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon
Affiliations
Review

The immune contexture in human tumours: impact on clinical outcome

Wolf Herman Fridman et al. Nat Rev Cancer. .

Abstract

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.

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