Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2012 Mar 14;2012(3):CD008679.
doi: 10.1002/14651858.CD008679.pub2.

Follow-up for improving psychological well being for women after a miscarriage

Affiliations
Meta-Analysis

Follow-up for improving psychological well being for women after a miscarriage

Fiona A Murphy et al. Cochrane Database Syst Rev. .

Abstract

Background: Miscarriage is the premature expulsion of an embryo or fetus from the uterus up to 23 weeks of pregnancy and weighing up to 500 grams. International studies using diagnostic tools have identified that some women suffer from anxiety, depression and grief after miscarriage. Psychological follow-up might detect those women who are at risk of psychological complications following miscarriage. This review is necessary as the evidence is equivocal on the benefits of psychological follow-up after miscarriage.

Objectives: Whether follow-up affects the psychological well being of women following miscarriage.

Search methods: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2011), reference lists of all retrieved papers and contacted professional and lay organisations to obtain any ongoing trials or unpublished data.

Selection criteria: Randomised controlled trials only.

Data collection and analysis: All potential trials for eligibility according to the criteria specified in the protocol by screening the titles and abstracts, retrieving full reports of potentially relevant trials for assessment. All review authors extracted data and checked for accuracy. No studies were published in duplicate. When data were missing and only the abstract was available, we attempted to contact the trial authors. We resolved any disagreement through discussion.

Main results: Six studies involving 1001 women were included. Three trials compared one counselling session with no counselling. There was no significant difference in psychological well being including anxiety, grief, depression avoidance and self-blame. One trial compared three one-hour counselling sessions with no counselling at four and 12 months. Some subscales showed statistical significance in favour of counselling and some in favour of no counselling. The results for two trials were given in narrative form as data were unavailable for meta-analyses. One trial compared multiple interventions. The other trial compared two counselling sessions with no counselling. Neither study favoured counselling.

Authors' conclusions: Evidence is insufficient to demonstrate that psychological support such as counselling is effective post-miscarriage. Further trials should be good quality, adequately-powered using standardised interventions and outcome measures at specific time points. The economic implications and women's satisfaction with psychological follow-up should also be explored in any future study.

PubMed Disclaimer

Conflict of interest statement

None known.

Figures

1
1
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
1.1
1.1. Analysis
Comparison 1 One counselling session versus no counselling (at four months), Outcome 1 Psychological well being.
2.1
2.1. Analysis
Comparison 2 Three one‐hour counselling sessions versus no counselling (at four months), Outcome 1 Psychological well being.
3.1
3.1. Analysis
Comparison 3 Three one‐hour counselling sessions versus no counselling (at 12 months), Outcome 1 Psychological well being.

Update of

References

References to studies included in this review

Adolfsson 2006 {published data only}
    1. Adolfsson A. The effect of structured second visit to midwifes in women with early miscarriages, a randomized study. 10th International Conference of Maternity Care Researchers; 2004 June 13‐16; Lund, Sweden. 2004:22. [CN‐00487510]
    1. Adolfsson A, Bertero C, Larsson PG. Effect of a structured follow‐up visit to a midwife on women with early miscarriage: a randomized study. Acta Obstetricia et Gynecologica Scandinavica 2006;85:330‐5. - PubMed
Lee 1996 {published data only}
    1. Lee C, Slade P, Lygo V. The influence of psychological debriefing on emotional adaptation in women following early miscarriage: a preliminary study. British Journal of Medical Psychology 1996;69(Pt 1):47‐58. - PubMed
Lok Hung 2006 {published and unpublished data}
    1. Lok IH. Psychological morbidity after miscarriage [thesis]. University of Hong Kong, 2006.
Nikčević 2007 {published data only}
    1. Nikčević AV, Kuczmierczyk AR, Nicolaides KH. The influence of medical and psychological interventions on women's distress after miscarriage. Journal of Psychosomatic Research 2007;63(3):283‐90. - PubMed
Swanson 1999 {published data only}
    1. Swanson KM. Effects of caring, measurement, and time on miscarriage impact and women's well‐being. Nursing Research 1999;48(6):288‐98. - PubMed
Swanson 2009 {published data only}
    1. Swanson KM, Chen HT, Graham CJ, Wojnar DM, Petras A. Resolution of depression and grief during the first year after miscarriage: a randomized controlled clinical trial of couples‐focused interventions. Journal of Women's Health 2009;18(8):1245‐57. - PMC - PubMed

References to studies excluded from this review

Broen 2004 {published data only}
    1. Broen AN, Moum TR, Bødtker AS, Ekeberg O. Psychological impact on women of miscarriage versus induced abortion: a 2‐year follow‐up study. Psychosomatic Medicine 2004;66(2):265‐71. - PubMed
Broen 2005 {published data only}
    1. Broen AN, Moum TR, Bødtker AS, Ekeberg O. The course of mental health after miscarriage and induced abortion: a longitudinal, five‐year follow‐up study. BMC Medicine 2005;3:265‐71. - PMC - PubMed
Cordle 1994 {published data only}
    1. Cordle CJ, Prettyman RJ. A 2‐year follow‐up of women who have experienced early miscarriage. Journal of Reproductive and Infant Psychology 1994;12:37‐43.
Jacobs 2000 {published data only}
    1. Jacobs J, Harvey J. Evaluation of an Australian miscarriage support programme. British Journal of Nursing 2000;9(1):22‐6. - PubMed
Lefkof 2002 {published data only}
    1. Lefkof J, Glazer G. Grief after miscarriage. Practical interventions can assist with far‐reaching loss. Advance for Nurse Practitioners 2002;10(10):79‐82. - PubMed
Luise 2002 {published data only}
    1. Luise C, Jermy K, Collons WP, Bourne TH. Expectant management of incomplete, spontaneous first‐trimester miscarriage: outcome according to initial ultrasound criteria and value of follow‐up visits. Ultrasound In Obstetrics & Gynecology 2002;19(6):580‐2. - PubMed
Neugebauer 2006 {published data only}
    1. Neugebauer R, Kline J, Markowitz JC, Bleiberg KL, Baxi L, Rosing MA, et al. Pilot randomized controlled trial of interpersonal counselling for subsyndromal depression following miscarriage. Journal of Clinical Psychiatry 2006;67(8):1299‐304. - PubMed
Neugebauer 2007 {published data only}
    1. Neugebauer R, Kline J, Bleiberg K, Baxi L, Markowitz JC, Rosing M, et al. Preliminary open trial of interpersonal counselling for subsyndromal depression following miscarriage. Depression and Anxiety 2007;24(3):219‐22. - PubMed
Nikčević 1998 {published data only}
    1. Nikcevic AV, Tunkel SA, Nicolaides KH. Psychological outcomes following missed abortions and provision of follow‐up care. Ultrasound in Obstetrics and Gynecology 1998;11(2):123‐8. - PubMed
Nikčević 2003 {published data only}
    1. Nikcevic AV. Development and evaluation of a miscarriage follow up clinic. Journal of Reproductive & Infant Psychology 2003;21(3):207‐17.
Rajan 1993 {published data only}
    1. L Rajan A Oakley. No pills for heartache: The importance of social support for women who suffer pregnancy loss. Journal of Reproductive and Infant Psychology 1993;11:75‐87.
Sejourne 2011 {published data only}
    1. Sejourne N, Callahan S, Chabrol H. [The efficiency of a brief support intervention for anxiety, depression and stress after miscarriage]. [French]. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction 2011;40(5):437‐43. - PubMed
Thaper 1992 {published data only}
    1. Thapar AK, Thapar A. Psychological sequelae of miscarriage: a controlled study using the General Health Questionnaire and the Hospital Anxiety and Depression scale. British Journal of General Practice 1992;42(356):94‐6. - PMC - PubMed

Additional references

Blohm 2008
    1. Blohm F, Friden B, Milsom I. A prospective longitudinal population‐based study of clinical miscarriage in an urban Swedish population. BJOG: An International Journal of Obstetrics & Gynaecology 2008;115(2):176‐83. - PubMed
Deeks 2001
    1. Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta‐analysis. In: Egger M, Davey Smith G, Altman DG editor(s). Systematic reviews in health care: meta‐analysis in context. London: BMJ Books, 2001.
Egger 1997
    1. Egger M, Smith GD, Schneider M, Minder C. Bias in meta‐analysis detected by a simple, graphical test. BMJ 1997;315:629‐34. - PMC - PubMed
Farquharson 2005
    1. Farquharson RG, Jauniaux E, Exalto N. Updated and revised nomenclature for description of early pregnancy events. Human Reproduction 2005;20:3008‐11. - PubMed
Flenady 2008
    1. Flenady V, Wilson T. Support for mothers, fathers and families after perinatal death. Cochrane Database of Systematic Reviews 2008, Issue 1. [DOI: 10.1002/14651858.CD000452.pub2] - DOI - PubMed
Frost 2007
    1. Frost J, Bradley H, Levitas R, Smith L, Garcia J. The loss of possibility: scientisation of death and the special case of early miscarriage. Sociology of Health and Illness 2007;29(7):1003‐22. - PubMed
Harbord 2006
    1. Harbord RM, Egger M, Sterne JA. A modified test for small‐study effects in meta‐analyses of controlled trials with binary endpoints. Statistics in Medicine 2006;25:3443‐57. - PubMed
Higgins 2011
    1. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org.
Malacrida 1998
    1. Malacrida C. Mourning the dreams. Alberta Canada: Qual Institute Press, 1998.
Mander 1997
    1. Mander R. Perinatal grief: understanding the bereaved and their carers. In: Alexander J, Roth C, Levy V editor(s). Midwifery Practice. Basingstoke: Macmillan, 1997:29‐50.
Nanda 2006
    1. Nanda K, Peloggia A, Grimes DA, Lopez LM, Nanda G. Expectant care versus surgical treatment for miscarriage. Cochrane Database of Systematic Reviews 2006, Issue 2. [DOI: 10.1002/14651858.CD003518.pub2] - DOI - PubMed
Neilson 2010
    1. Neilson JP, Gyte GML, Hickey M, Vazquez JC, Dou L. Medical treatments for incomplete miscarriage (less than 24 weeks). Cochrane Database of Systematic Reviews 2010, Issue 1. [DOI: 10.1002/14651858.CD007223.pub2] - DOI - PMC - PubMed
Neugebauer 1997
    1. Neugebauer R, Kline J, Shrout P, Skodol A, O’Connor P, Geller P, et al. Major depressive disorder in the 6 months after miscarriage. JAMA 1997;277(5):383‐8. - PubMed
Nikcevic 1999
    1. Nikcevic A, Tunkel S, Kuczmierczyk A. Investigation of the cause of miscarriage and its influence on women’s psychological distress. British Journal of Obstetrics and Gynaecology 1999;106(8):808‐13. - PubMed
RCOG 2006
    1. RCOG. Management of Early Pregnancy Loss. London: Royal College of Obstetricians and Gynaecologists, 2006.
RevMan 2011 [Computer program]
    1. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Stirtzinger 1999
    1. Stirtzinger RM, Robinson DE, Stewart DE, Ralevski E. Parameters of grieving in spontaneous abortion. International Journal of Psychiatry in Medicine 1999;29:235‐49. - PubMed
Stratton 2008
    1. Stratton K, Lloyd L. Hospital‐based interventions at and following miscarriage: literature to inform a research‐practice initiative. Australian and New Zealand Journal of Obstetrics and Gynaecology 2008;48:5‐11. - PubMed
Trinder 2006
    1. Trinder J, Brocklehurst P, Porter R, Read M, Vyas S, Smith L. Management of miscarriage: expectant, medical, or surgical? Results of randomised controlled trial (miscarriage treatment (MIST) trial). BMJ 2006;332:1235‐40. - PMC - PubMed
WHO 2001
    1. WHO. Definitions and indicators in family planning, maternal & child health and reproductive health. WHO Regional Strategy on Sexual and Reproductive Health. Geneva: World Health Organization, 2001.