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Randomized Controlled Trial
. 2012 Sep;21(3):205-21.
doi: 10.1002/mpr.1352. Epub 2012 Mar 15.

Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods

Nikie Korver  1 , Piotr J Quee, Heleen B M Boos, Claudia J P Simons, Lieuwe de Haan; GROUP investigators
Collaborators, Affiliations
Randomized Controlled Trial

Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods

Nikie Korver et al. Int J Methods Psychiatr Res. 2012 Sep.

Abstract

Objective: A longitudinal focus on gene-environment vulnerability and resilience in both patients, their unaffected family members and non-related controls offers the opportunity to elucidate etiological and pathogenetic factors influencing the onset and course of psychotic disorders. The current paper delineates the objectives, sample characteristics, recruitment and assessment procedures of the Genetic Risk and Outcome of Psychoses (GROUP) study.

Methods: A naturalistic longitudinal cohort study with assessments at baseline, after three and six years of follow-up. The study is conducted by a consortium of four university psychiatric centres, with their affiliated mental health care institutions in the Netherlands covering more than 7.5 million inhabitants. Extensive assessment of genetic factors, environmental factors, (endo)phenotypes, and outcome.

Results: At baseline, 1120 patients, 1057 siblings, 919 parents and 590 healthy controls were included.

Conclusion: The GROUP study will contribute to insight in risk and protective factors in the aetiology of non-affective psychotic disorders, and in the variation in their course and outcome.

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Figures

Figure 1
Figure 1
Flow diagram of the GROUP‐project organization structure, referred participants and collected data. aNineteen parents and 24 siblings received a patient status.
See this image and copyright information in PMC

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