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. 1979 May;30(2):515-22.
doi: 10.1128/JVI.30.2.515-522.1979.

Polyoma viruses with mutations at endonuclease HindII site 1: alterations at the COOH terminus of VP1

M M Bendig, W R Folk, W Gibson

Polyoma viruses with mutations at endonuclease HindII site 1: alterations at the COOH terminus of VP1

M M Bendig et al. J Virol. 1979 May.

Abstract

Four mutants of polyoma virus lacking endonuclease HindII site 1 were isolated and characterized with respect to the VP1 coding sequence. Three of these mutants had deletions that removed 0.2 to 0.3% of the genome. All three deletion mutants encoded VP1 proteins that were smaller than wild type and that lacked one or more tryptic peptides normally found in the wild-type VP1 protein. Our results suggest the HindII site 1 is at, or very near, the carboxy terminal end of the coding sequence for VP1. A model for the peptide organization in that region is presented.

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References

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