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Comment
. 2012 Mar 16;335(6074):1302; author reply 1302.
doi: 10.1126/science.1210419.

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome"

Wei Lin  1 , Robert Piskol, Meng How Tan, Jin Billy Li
Affiliations
Comment

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome"

Wei Lin et al. Science. .

Abstract

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.

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