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. 2012 Mar 16;13(1):21.
doi: 10.1186/1465-9921-13-21.

Risk factors for morbidity and death in non-cystic fibrosis bronchiectasis: a retrospective cross-sectional analysis of CT diagnosed bronchiectatic patients

Pieter Christian Goeminne  1 , Hans Scheers, Ann Decraene, Sven Seys, Lieven Joseph Dupont
Affiliations

Risk factors for morbidity and death in non-cystic fibrosis bronchiectasis: a retrospective cross-sectional analysis of CT diagnosed bronchiectatic patients

Pieter Christian Goeminne et al. Respir Res. .

Abstract

Introduction: There is a relative lack of information about the death rate and morbidity of non-cystic fibrosis bronchiectasis and most studies are limited due to referral bias. We wanted to assess death rate and morbidity in those patients at our hospital.

Methods: Adult patients seen at our department between June 2006 and November 2009 were recruited if the key string "bronchiect-" was mentioned in electronic clinical records and if chest CT imaging was available. Clinical records of all patients with confirmed radiologic diagnosis of bronchiectasis were reviewed and clinical characteristics were analyzed.

Results: 539 patients with a radiographic diagnosis of non-cystic fibrosis bronchiectasis were identified in a retrospective cross-sectional analysis giving a prevalence of 2.6% in our hospital population. A wide range of etiologies was found with idiopathic bronchiectasis in 26%. In the 41 months interval, 57 patients (10.6%) died. We found a median exacerbation rate of 1.94 per year. Bacterial colonization status was associated with more deaths, exacerbation rate, symptoms and reduced pulmonary function. Pulmonary hypertension was found in 48% of our patients.

Conclusions: We evaluated a large non-cystic fibrosis bronchiectasis population, and provided new epidemiological data on associations between clinical characteristics and deaths and morbidity in these patients.

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Figures

Figure 1
Figure 1
Patient selection algorithm of adult patient files reviewed. CF = Cystic fibrosis; CFLD = CF Like Disease; BX = Bronchiectasis; CT = Computer Tomography; LTX = Lung transplant patients; non-CF Bx = Non-Cystic Fibrosis Bronchiectasis.
Figure 2
Figure 2
Underlying etiology of the studied population. ABPA = Allergic Bronchopulmonary Aspergillosis; COPD = Chronic Obstructive Lung Disease; PCD = Primary Ciliary Dyskinesia, NCFB = Non Cystic Fibrosis bronchiectasis
Figure 3
Figure 3
Percentage of bacteria present in sputum or bronchoalveolar lavage culture of NCFB patients. Only bacteria with a prevalence of more than 5% are shown
See this image and copyright information in PMC

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