Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Apr;159(4):205-17.
doi: 10.1016/j.trsl.2012.01.007. Epub 2012 Feb 7.

Biomarkers in acute lung injury

Maneesh Bhargava  1 , Chris H Wendt
Affiliations
Review

Biomarkers in acute lung injury

Maneesh Bhargava et al. Transl Res. 2012 Apr.

Abstract

Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) result in high permeability pulmonary edema causing hypoxic respiratory failure with high morbidity and mortality. As the population ages, the incidence of ALI is expected to rise. Over the last decade, several studies have identified biomarkers in plasma and bronchoalveolar lavage fluid providing important insights into the mechanisms involved in the pathophysiology of ALI. Several biomarkers have been validated in subjects from the large, multicenter ARDS clinical trials network. Despite these studies, no single or group of biomarkers has made it into routine clinical practice. New high throughput "omics" techniques promise improved understanding of the biologic processes in the pathogenesis in ALI and possibly new biomarkers that predict disease and outcomes. In this article, we review the current knowledge on biomarkers in ALI.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Time course in Acute Lung Injury. Early in the course the alveoli are filled with protein rich permeability pulmonary edema. By day five to seven, there is proliferation of type II alveolar epithelial cells, leading to repithelialization and restoration of the alveolar structure or progressive fibrosis and irreversible hypoxic respiratory failure. (Redrawn from Katzenstein AA, Askin FB. Surgical Pathology of Non-neoplastic Lung)
See this image and copyright information in PMC

References

    1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967 Aug 12;2(7511):319–323. - PubMed
    1. Suratt BT, Parsons PE. Mechanisms of acute lung injury/acute respiratory distress syndrome. Clin Chest Med. 2006 Dec;27(4):579–589. [Research Support, N.I.H., Extramural Review]. abstract viii. - PubMed
    1. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005 Oct 20;353(16):1685–1693. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. - PubMed
    1. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22;351(4):327–336. [Clinical Trial Comparative Study Multicenter Study Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S.]. - PubMed
    1. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000 May 4;342(18):1301–1308. [Clinical Trial Comparative Study Multicenter Study Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S.]. - PubMed

MeSH terms