Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May;187(5):1876-81.
doi: 10.1016/j.juro.2011.12.058. Epub 2012 Mar 16.

Therapeutic potential of SOX2 inhibition for embryonal carcinoma

Hiroshi Ushida  1 , Tokuhiro Chano, Kahori Minami, Hiroko Kita, Takahiro Kawakami, Hidetoshi Okabe, Yusaku Okada, Keisei Okamoto
Affiliations

Therapeutic potential of SOX2 inhibition for embryonal carcinoma

Hiroshi Ushida et al. J Urol. 2012 May.

Abstract

Purpose: Some nonseminomatous germ cell tumors are resistant to any type of chemotherapy. Control of embryonal carcinoma cells is crucial to manage nonseminomatous germ cell tumors. We established SOX2 targeting therapy in an embryonal carcinoma model.

Materials and methods: SOX2 expression was evaluated in a series of testicular germ cell tumor tissue samples. The antitumor effect of SOX2 knockdown was analyzed in vitro and in vivo using an embryonal carcinoma model.

Results: In testicular germ cell tumor tissue SOX2 was expressed in the foci of embryonal carcinoma but negative in seminoma and yolk sac tumors. In an embryonal carcinoma model SOX2-siRNA induced apoptotic cell death in vitro and significant growth suppression in vivo.

Conclusions: This study shows the therapeutic potential of SOX2 silencing for embryonal carcinoma. However, further improvements are needed in SOX2-siRNA delivery to the tumor.

PubMed Disclaimer

Publication types

MeSH terms

Substances