Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Apr;7(4):768-9.
doi: 10.1097/JTO.0b013e31824c9485.

ALK-rearranged lung cancer: adenosquamous lung cancer masquerading as pure squamous carcinoma

Jamie E Chaft  1 , Natasha Rekhtman, Marc Ladanyi, Gregory J Riely
Affiliations
Case Reports

ALK-rearranged lung cancer: adenosquamous lung cancer masquerading as pure squamous carcinoma

Jamie E Chaft et al. J Thorac Oncol. 2012 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Squamous histology in cervical lymph node metastasis.
Figure 2
Figure 2
Adenocarcinoma histology in the resected primary tumor. Abundant extracellular mucin and focal signet-ring cells are the features typical of EML4-ALK-rearranged AD.
Figure 3
Figure 3
ALK FISH revealing rearrangement in a cervical lymph node metastasis with squamous histology. ALK rearrangement was also found in the primary tumor with adenocarcinoma histology (not shown).
See this image and copyright information in PMC

References

    1. Takamori S, Noguchi M, Morinaga S, et al. Clinicopathologic characteristics of adenosquamous carcinoma of the lung. Cancer. 1991;67:649–654. - PubMed
    1. Rekhtman N, Paik PK, Arcila ME, et al. Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mtuations. Clin Cancer Res. 2011 in press. - PMC - PubMed
    1. Tochigi N, Dacic S, Nikiforova M, Cieply KM, Yousem SA. Adenosquamous carcinoma of the lung: a microdissection study of KRAS and EGFR mutational and amplification status in a western patient population. Am J Clin Pathol. 2011;135:783–789. - PubMed
    1. Yoshida A, Tsuta K, Nakamura H, et al. Comprehensive histologic analysis of ALK-rearranged lung carcinomas. Am J Surg Pathol. 2011;35:1226–1234. - PubMed
    1. Klempner SJ, Cohen DW, Costa DB. ALK Translocation in Non-small Cell Lung Cancer with Adenocarcinoma and Squamous Cell Carcinoma Markers. J Thorac Oncol. 2011;6:1439–1440. - PMC - PubMed

Publication types

MeSH terms