Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May;29(5):391-6.
doi: 10.1007/s10815-012-9732-z. Epub 2012 Mar 18.

The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles

Michael P Diamond  1 , Susan Willman, Philip Chenette, Marcelle I Cedars
Affiliations

The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles

Michael P Diamond et al. J Assist Reprod Genet. 2012 May.

Abstract

Purpose: To provide a rationale for continuation of efforts to improve the outcome of Assisted Reproductive Technology outcomes, thereby increasing the likelihood of the live birth of healthy neonates.

Methods: Description of rationale and a framework leading to improvement in Assisted Reproductive Technology outcomes.

Results: The opportunity for improvement in the success rate for Assisted Reproductive Technology outcome is predicated on selection of the highest quality embryo(s) for transfer. However, such approaches must be balanced by a limit to the number of embryos transferred so as to reduce the risk for multiple births and particularly higher order multiple gestations. Blastocyst transfer offers one such successful approach, but is confounded by suggestions of an increased risk of both pregnancy complications and epigenetic disorders.

Conclusion: There is a need for development of approaches which, individually or in combination, may assist in the early detection of embryos destined to develop into blastocysts.

PubMed Disclaimer

References

    1. Bergh T, Ericson A, Hillensjo T, Nygren KG, Wennerholm UB. Deliveries and children born after in-vitro fertilization in Sweden 1982–95: a retrospective cohort study. Lancet. 1999;354(9190):1579–85. doi: 10.1016/S0140-6736(99)04345-7. - DOI - PubMed
    1. Blake DA, Farquhar CM, Johnson N, Proctor M. Clevage stage versus blastocyst embryo stage embryo transfer in assisted conception. Cochrane Database System Reviews 2007;CD002118, doi:10.1002/14651858.CD002118.pub3 - PubMed
    1. Blennborn M, Nilsson S, Hillervik C, Hellberg D. The couple’s decision-making in IVF: one or two embryos at a transfer? Hum Reprod. 2005;20:292–7. doi: 10.1093/humrep/deh785. - DOI - PubMed
    1. Botting BJ, Davies IM, Macfarlane AJ. Recent trends in the incidence of multiple births and associated mortality. Arch Dis Child. 1987;62:941–50. doi: 10.1136/adc.62.9.941. - DOI - PMC - PubMed
    1. Callahan TL, Hall JE, Ettner SL, Christiansen CL, Greene MF, Crowley WF., Jr The economic impact of multiple-gestation pregnancies and the contribution of assisted-reproduction techniques to the incidence. N Engl J Med. 1994;331(4):244–9. doi: 10.1056/NEJM199407283310407. - DOI - PubMed

Publication types