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Review
. 2012 Feb;3(2):117-22.
doi: 10.1007/s13238-012-2018-5. Epub 2012 Mar 17.

Multifaceted functions of Siva-1: more than an Indian God of Destruction

Yide Mei  1 , Mian Wu
Affiliations
Review

Multifaceted functions of Siva-1: more than an Indian God of Destruction

Yide Mei et al. Protein Cell. 2012 Feb.

Abstract

Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppressing tumor metastasis, and their potential implications.

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References

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