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. 2012 Jun;157(6):1177-82.
doi: 10.1007/s00705-012-1273-3. Epub 2012 Mar 20.

VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation

Jelle Matthijnssens  1 , Peter H Otto, Max Ciarlet, Ulrich Desselberger, Marc Van Ranst, Reimar Johne
Affiliations

VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation

Jelle Matthijnssens et al. Arch Virol. 2012 Jun.

Abstract

Indirect immunofluorescence techniques targeting the rotavirus (RV) protein VP6 are used to differentiate RV species. The ICTV recognizes RV species A to E and two tentative species, F and G. A potential new RV species, ADRV-N, has been described. Phylogenetic trees and pairwise identity frequency graphs were constructed with more than 400 available VP6 sequences and seven newly determined VP6 sequences of RVD strains. All RV species were separated into distinct phylogenetic clusters. An amino acid sequence cutoff value of 53% firmly permitted differentiation of RV species, and ADRV-N was tentatively assigned to a novel RV species H (RVH).

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