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. 2012 Jun;56(6):3395-8.
doi: 10.1128/AAC.06364-11. Epub 2012 Mar 19.

The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae

Meredith G Jernigan  1 , Ellen G Press, M Hong Nguyen, Cornelius J Clancy, Ryan K Shields
Affiliations

The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae

Meredith G Jernigan et al. Antimicrob Agents Chemother. 2012 Jun.

Abstract

We tested two-drug combinations of doripenem, colistin, gentamicin, and doxycycline against 12 carbapenemase-producing Klebsiella pneumoniae (KPC) isolates by time-kill. The combination of doripenem and colistin reduced the starting inocula by 2 logs for each isolate (range, 2.02 to 6.01 log(10)) and was bactericidal and synergistic against 75 and 50%, respectively. Among colistin- and pan-drug-resistant isolates, synergy was identified in 60 and 67%, respectively. All other combinations were inferior. We are currently evaluating the combination of doripenem and colistin as a frontline therapy for KPC infection.

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Figures

Fig 1
Fig 1
Representative area under the curve (AUC) for isolates alone and in combination for the following drug combinations: (a) colistin (dark gray) plus doripenem (light gray); (b) gentamicin (light gray) plus doxycycline (dark gray); and (c) doripenem (light gray) plus doxycycline (dark gray). Black shading represents the AUC for two-drug combinations.
See this image and copyright information in PMC

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