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. 2012 May;35(5):1047-9.
doi: 10.2337/dc11-1511. Epub 2012 Mar 19.

Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications

Yu Sun  1 , Ya-Hui Chang, Hua-Fen Chen, Ying-Hwa Su, Hui-Fang Su, Chung-Yi Li
Affiliations

Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications

Yu Sun et al. Diabetes Care. 2012 May.

Abstract

Objective: We retrospectively assessed the age- and sex-specific incidence and relative risk of Parkinson disease (PD) in Taiwan's diabetic population.

Research design and methods: Study cohort included 603,416 diabetic patients and 472,188 nondiabetic control subjects. Incidence rate and relative risk of PD (ICD-9-CM 332.0) were evaluated.

Results: The incidence of PD was 3.59 and 2.15 per 10,000 person-years for the diabetic and control group, respectively, representing a covariate adjusted hazard ratio (HR) of 1.61 (95% CI 1.56-1.66), which was substantially reduced to 1.37 (1.32-1.41) after adjusting for medical visits. Diabetes was associated with a significantly elevated risk of PD in all sex and age stratifications except in young women, with the highest HR noted for young men aged 21-40 years (2.10 [1.01-4.42]), followed by women aged 41-60 (2.05 [1.82-2.30]) and >60 years (1.65 [1.58-1.73]).

Conclusions: Diabetes is associated with an increased risk of PD onset in a Chinese population, and the relation is stronger in women and younger patients.

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