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Review
. 2012 May;34(3):365-82.
doi: 10.1007/s00281-012-0306-z. Epub 2012 Mar 21.

Glycosylation of IgA1 and pathogenesis of IgA nephropathy

Jan Novak  1 , Bruce A Julian, Jiri Mestecky, Matthew B Renfrow
Affiliations
Review

Glycosylation of IgA1 and pathogenesis of IgA nephropathy

Jan Novak et al. Semin Immunopathol. 2012 May.

Abstract

IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune disease. Galactose-deficient IgA1 is recognized by unique autoantibodies, resulting in the formation of pathogenic immune complexes that ultimately induce glomerular injury. Thus, formation of the galactose-deficient IgA1-containing immune complexes is a critical factor in the pathogenesis of IgA nephropathy. Studies of molecular defects of IgA1 can define new biomarkers specific for IgA nephropathy that can be developed into clinical assays to aid in the diagnosis, assessment of prognosis, and monitoring of disease progression.

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