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. 2012 Mar;246(1):5-13.
doi: 10.1111/j.1600-065X.2012.01111.x.

Celebrating 25 years of NF-κB research

Sankar Ghosh  1 , Matthew S Hayden
Affiliations

Celebrating 25 years of NF-κB research

Sankar Ghosh et al. Immunol Rev. 2012 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1. NF-κB is a central regulator of the transcriptional responses to a wide variety of physiological and environmental stimuli
Signals ranging from pro-inflammatory cytokines to stresses including reactive oxygen species (ROS), ultraviolet light (UV) and DNA double strand breaks (DSB), to engagement of antigen receptors lead to activation of NF-κB. Several inherited and somatically acquired mutations can also lead to activation of NF-κB. NF-κB transcriptional programs induce a wide variety of genes (http://www.nf-kb.org). These transcriptional programs have far-reaching biological consequences and include survival factors, growth factors, cytokines, chemokines, numerous core mediators of adaptive and innate immunity, as well as micro-RNAs.
See this image and copyright information in PMC

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