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Randomized Controlled Trial
. 2012 Mar 21:7:25.
doi: 10.1186/1749-8090-7-25.

Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study

Georgios I Tagarakis  1 , Christos Voucharas, Fani Tsolaki, Marios E Daskalopoulos, Vassilios Papaliagkas, Charalampos Parisis, Eleni Gogaki, Iotalias Tsagalas, Iotalias Sataitidis, Magda Tsolaki, Nikolaos B Tsilimingas
Affiliations
Randomized Controlled Trial

Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study

Georgios I Tagarakis et al. J Cardiothorac Surg. .

Abstract

Background: To investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium.

Methods: We included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc.).

Results: Both ondasetron and haloperidol had very good delirium controlling effects, without statistically significant differences. DISCUSSION-CONCLUSIONS: Ondasetron and haloperidol are efficient agents as far as the treatment of postcardiotomy delirium is concerned. As, in addition, ondasetron bares milder side-effects, we believe this could be the agent of choice in patients developing postcardiotomy delirium in the future.

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Figures

Figure 1
Figure 1
Chemical structure of ondasetron.
Figure 2
Figure 2
Chemical structure of haloperidol.
See this image and copyright information in PMC

References

    1. Tardiff BE, Newman MF, Saunders AM, Strittmatter WJ, Blumenthal JA, White WD. et al. Preliminary report of a genetic basis for cognitive decline after cardiac operations. The neurologic outcome research group of the Duke heart center. Ann Thorac Surg. 1997;64(3):715–720. doi: 10.1016/S0003-4975(97)00757-1. - DOI - PubMed
    1. Tagarakis GI, Tsolaki-Tagaraki F, Tsolaki M, Diegeler A, Tsilimingas NB, Papassotiropoulos A. The role of apolipoprotein E in cognitive decline and delirium after bypass heart operations. Am J Alzheimers Dis Other Demen. 2007. pp. 223–228. - PMC - PubMed
    1. Bucerius J, Gummert JF, Walther T, Doll N, Falk V, Mohr FW. Diabetes in patients undergoing coronary artery bypass grafting. Impact on perioperative outcome. Z Kardiologie. 2005;94(9):575–582. doi: 10.1007/s00392-005-0273-7. - DOI - PubMed
    1. Tagarakis GI, Tsolaki F, Daskalopoulos ME, Karantzis I, Baddour AS, Karangelis D. et al. Visual disorders or "eye stroke"after heart surgery: can we prevent it? Chir Ital. 2009;61(5-6):623–625. - PubMed
    1. Bucerius J, Gummert JF, Borger MA, Walther T, Doll N, Falk V, Schmitt DV, Mohr FW. Predictors of delirium after cardiac surgery delirium: effect of beating-heart (off-pump) surgery. J Thorac Cardiovasc Surg. 2004;127(1):57–64. doi: 10.1016/S0022-5223(03)01281-9. - DOI - PubMed

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