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. 2012 Mar 20;21(3):327-9.
doi: 10.1016/j.ccr.2012.03.002.

Targeting tumor architecture to favor drug penetration: a new weapon to combat chemoresistance in pancreatic cancer?

Man Yu  1 , Ian F Tannock
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Targeting tumor architecture to favor drug penetration: a new weapon to combat chemoresistance in pancreatic cancer?

Man Yu et al. Cancer Cell. .
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Abstract

Pancreatic ductal adenocarcinoma (PDA) responds poorly to chemotherapy. In this issue of Cancer Cell, Provenzano et al. identify hyaluronan as a pivotal determinant of elevated interstitial fluid pressures (IFP) and vascular collapse in PDA. PEGPH20 treatment ablates stromal hyaluronan, normalizes IFP, and increases accessibility of tumor cells to anticancer drugs.

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