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Comment
. 2012 Apr 3;109(14):5144-5.
doi: 10.1073/pnas.1202905109. Epub 2012 Mar 21.

Battle of the sexes: conflict over dosage-sensitive genes and the origin of X chromosome inactivation

Alison E Wright  1 , Judith E Mank
Affiliations
Comment

Battle of the sexes: conflict over dosage-sensitive genes and the origin of X chromosome inactivation

Alison E Wright et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Sexual conflict over X chromosome transcription and the evolution of XCI. The single copy of the X chromosome in males results in selection to hypertranscribe dosage-sensitive X-linked genes (A), which balances out the X and autosomes in males but results in overtranscription of X-linked genes in females (B). In both A and B, males (blue) and females (red) have distinctly different transcriptional optima. This sexual conflict is resolved by XCI, which equalizes effective gene dose and realigns optimal transcription levels for both sexes (C).
See this image and copyright information in PMC

Comment on

References

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