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Review
. 2011 Nov;1(5):419-22.
doi: 10.1016/j.coviro.2011.09.001. Epub 2011 Oct 4.

Lethal mutagenesis of viruses

Celia Perales  1 , Verónica Martín, Esteban Domingo
Affiliations
Review

Lethal mutagenesis of viruses

Celia Perales et al. Curr Opin Virol. 2011 Nov.

Abstract

Lethal mutagenesis aims at extinguishing viruses by increased mutagenesis prompted by virus-specific mutagenic agents, mainly nucleoside analogues. It is derived from the error threshold relationship of quasispecies theory, and it is slowly finding its way towards a clinical application. We summarize the current situation of research in this field of antiviral therapy.

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