Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Apr;23(2):307-22, ix.
doi: 10.1016/j.nec.2012.01.007.

Temozolomide and other potential agents for the treatment of glioblastoma multiforme

Daniel T Nagasawa  1 , Frances Chow, Andrew Yew, Won Kim, Nicole Cremer, Isaac Yang
Affiliations
Review

Temozolomide and other potential agents for the treatment of glioblastoma multiforme

Daniel T Nagasawa et al. Neurosurg Clin N Am. 2012 Apr.

Abstract

This article provides historical and recent perspectives related to the use of temozolomide for the treatment of glioblastoma multiforme. Temozolomide has quickly become part of the standard of care for the modern treatment of stage IV glioblastoma multiforme since its approval in 2005. Yet despite its improvements from previous therapies, median survival remains approximately 15 months, with a 2-year survival rate of 8% to 26%. The mechanism of action of this chemotherapeutic agent, conferred advantages and limitations, treatment resistance and rescue, and potential targets of future research are discussed.

PubMed Disclaimer

MeSH terms