Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep;33(8):1525-9.
doi: 10.3174/ajnr.A2987. Epub 2012 Mar 22.

MR imaging findings of the intraspinal meningeal melanocytoma: correlation with histopathologic findings

G Q Hou  1 , J C Sun, X J Zhang, B X Shen, X J Zhu, L Liang, X L Zhang
Affiliations

MR imaging findings of the intraspinal meningeal melanocytoma: correlation with histopathologic findings

G Q Hou et al. AJNR Am J Neuroradiol. 2012 Sep.

Abstract

Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.

PubMed Disclaimer

Figures

Fig 1.
Fig 1.
In case 1 (A and B), 3 lesions are shown on sagittal nonenhanced MR images of the cervical vertebrae at the C4-T2 level. In case 2 (C and D), the lesion is shown on sagittal nonenhanced MR images of the thoracic vertebrae at the T7-T8 level. In case 3, the lesion is shown on sagittal (E) and coronal (F) nonenhanced MR images of the thoracic vertebrae at the T11-T12 level.
Fig 2.
Fig 2.
In case 1, the sagittal (A) and axial (D) contrast-enhanced T1WI and morphologic changes (G, HE original magnification ×400) of the lesion are seen. In case 2, the sagittal (B) and axial (E) contrast-enhanced T1WI sequences and morphologic changes (H, HE original magnification ×200) of the lesion are seen. In case 3, the sagittal (C) and axial (F) contrast-enhanced T1WI sequence and morphologic changes (I, HE original magnification ×400) of the lesion are shown.
Fig 3.
Fig 3.
IHC detection of MM (DAB stain). The tumor cells have a negative reaction to the EMA antibody (A, original magnification ×200) but positive reactions to vimentin (B, ×200), HMB-45 (C, original magnification ×400), and S-100 (D, original magnification ×200).
See this image and copyright information in PMC

References

    1. Kwon SC, Rhim SC, Lee DH, et al. . Primary malignant melanoma of the cervical spinal nerve root. Yonsei Med J 2004; 45: 345– 48 - PubMed
    1. El-Khashab M, Koral K, Bowers DC, et al. . Intermediate grade meningeal melanocytoma of cervical spine. Childs Nerv Syst 2009; 25: 407– 10 - PubMed
    1. Limas C, Tio FO. Meningeal melanocytoma (“melanotic meningioma”): its melanocytic origin as revealed by electron microscopy. Cancer 1972; 30: 1286– 94 - PubMed
    1. Czarnecki EJ, Silbergleit R, Gutierrez JA. MR of spinal meningeal melanocytoma. AJNR Am J Neuroradiol 1997; 18: 180– 82 - PMC - PubMed
    1. Liubinas SV, Maartens N, Drummond KJ. Primary melanocytic neoplasms of the central nervous system. J Clin Neurosci 2010; 17: 1227– 32 - PubMed