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. 2012 May;7(5):835-41.
doi: 10.2215/CJN.09990911. Epub 2012 Mar 22.

Living donor age and kidney allograft half-life: implications for living donor paired exchange programs

Peter Chang  1 , Jagbir Gill, James Dong, Caren Rose, Howard Yan, David Landsberg, Edward H Cole, John S Gill
Affiliations

Living donor age and kidney allograft half-life: implications for living donor paired exchange programs

Peter Chang et al. Clin J Am Soc Nephrol. 2012 May.

Abstract

Background and objectives: Living donor paired exchange programs assume that kidneys from living donors are of comparable quality and anticipated longevity. This study determined actual allograft t(1/2) within different recipient age groups (10-year increments) as a function of donor age (5-year increments), and juxtaposed these results against the probabilities of deceased donor transplantation, and exclusion from transplantation (death or removal from the wait-list).

Design, setting, participants, & measurements: Data from the US Renal Data System (transplant dates 1988-2003 with follow-up through September 2007) were used to determine allograft t(1/2), whereas data from patients on the United Network for Organ Sharing waiting list between 2003 and 2005 (with follow-up through February 2010) were used to determine wait-list outcomes.

Results: With the exception of recipients aged 18-39 years, who had the best outcomes with donors aged 18-39 years, living donor age between 18 and 64 years had minimal effect on allograft t(1/2) (difference of 1-2 years with no graded association). The probability of deceased donor transplantation after 3 years of wait-listing ranged from 21% to 66% by blood type and level of sensitization, whereas the probability of being excluded from transplantation ranged from 6% to 27% by age, race, and primary renal disease.

Conclusions: With the exception of recipients aged 18-39 years, living donor age between 18 and 64 years has minimal effect on allograft survival.

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References

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