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Comment
. 2012 Apr;61(4):780-1.
doi: 10.2337/db12-0091.

ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes

Bryan O'Sullivan-Murphy  1 , Fumihiko Urano
Affiliations
Comment

ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes

Bryan O'Sullivan-Murphy et al. Diabetes. 2012 Apr.
No abstract available

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Figures

FIG. 1.
FIG. 1.
ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes. ER-stressed β-cells in early type 1 diabetes could eventually die through NF-κB signaling and lead to frank diabetes. Another possibility is that ER-stressed β-cells may produce neo-autoantigens and trigger autoimmunity, leading to a severe infiltration of T cells into islets. (A high-quality color representation of this figure is available in the online issue.)
See this image and copyright information in PMC

Comment on

References

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