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Comment
. 2012 Mar 23;36(3):313-5.
doi: 10.1016/j.immuni.2012.03.005.

Dangerous liaisons: mitochondrial DNA meets the NLRP3 inflammasome

Fabio Martinon  1
Affiliations
Free article
Comment

Dangerous liaisons: mitochondrial DNA meets the NLRP3 inflammasome

Fabio Martinon. Immunity. .
Free article

Abstract

Danger signals released by damaged organelles can promote inflammation. In this issue of Immunity, Shimada et al. (2012) report that oxidized DNA, released by mitochondria, directly binds and activates the NLRP3 inflammasome.

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  • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
    Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. Shimada K, et al. Immunity. 2012 Mar 23;36(3):401-14. doi: 10.1016/j.immuni.2012.01.009. Epub 2012 Feb 16. Immunity. 2012. PMID: 22342844 Free PMC article.

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