doi: 10.1126/science.224461.
Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons
- PMID: 224461
- DOI: 10.1126/science.224461
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Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons
Science.
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Abstract
The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.
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