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. 2012 Jun;205(11):1642-5.
doi: 10.1093/infdis/jis265. Epub 2012 Mar 23.

Combination antiviral therapy for influenza: predictions from modeling of human infections

Alan S Perelson  1 , Libin Rong, Frederick G Hayden
Affiliations

Combination antiviral therapy for influenza: predictions from modeling of human infections

Alan S Perelson et al. J Infect Dis. 2012 Jun.

Abstract

Emergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination antiviral therapy might overcome this problem. Here, we estimate that all possible single mutants and a sizeable fraction of double mutants are generated during an uncomplicated influenza infection. While most of them may sustain a fitness cost, some variants may confer drug resistance and be selected during therapy. We argue that a triple combination regimen would markedly reduce the risk of antiviral resistance emergence in seasonal and pandemic influenza viruses, especially in seriously ill or immunocompromised hosts.

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