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. 2012 Mar;50(2):169-75.
doi: 10.3164/jcbn.11-75. Epub 2011 Nov 11.

Different gastoroesophageal reflux symptoms of middle-aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients

Yasuo Shimizu  1 , Kunio Dobashi, Motoyasu Kusano, Masatomo Mori
Affiliations

Different gastoroesophageal reflux symptoms of middle-aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients

Yasuo Shimizu et al. J Clin Biochem Nutr. 2012 Mar.

Abstract

Symptomatic differences and the impact of gastroesophageal reflux disease (GERD) have not been clarified in patients with asthma and chronic obstructive pulmonary disease (COPD). The purpose of this study is to assess the differences of GERD symptoms among asthma, COPD, and disease control patients, and determine the impact of GERD symptoms on exacerbation of asthma or COPD by using a new questionnaire for GERD. A total of 120 subjects underwent assessment with the frequency scale for the symptoms of GERD (FSSG) questionnaire, including 40 age-matched patients in each of the asthma, COPD, and disease control groups. Asthma and control patients had more regurgitation-related symptoms than COPD patients (p<0.05), while COPD patients had more dysmotility-related symptoms than asthma patients (p<0.01) or disease control patients (p<0.01). The most distinctive symptom of asthma patients with GERD was an unusual sensation in the throat, while bloated stomach was the chief symptom of COPD patients with GERD, and these symptoms were associated with disease exacerbations. The presence of GERD diagnosed by the total score of FSSG influences the exacerbation of COPD. GERD symptoms differed between asthma and COPD patients, and the presence of GERD diagnosed by the FSSG influences the exacerbation of COPD.

Keywords: COPD; FSSG; GERD; asthma; dismotility.

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Figures

Fig. 1
Fig. 1
Chief symptoms of asthma patients (n = 40), COPD patients (n = 40), and disease control patients (n = 40). The total score for acid regurgitation-related symptoms (questions 1, 4, 6, 7, 9, 10, and 12) and the total score for dysmotility-related symptoms (questions 2, 3, 5, 8, and 11) were compared. The number of patients in each group with a higher score for acid regurgitation symptoms (A>M), the same score for both symptoms (A = M), or a higher score for dysmotility symptoms (A<M) was determined. *Significant difference between asthma and COPD. #Significant difference between COPD and disease controls.
Fig. 2
Fig. 2
Chief symptoms in asthma patients (n = 10), COPD patients (n = 13) and disease control patients (n = 11) who were diagnosed as having GERD by the FSSG survey in each group. The total score for acid regurgitation-related symptoms (questions 1, 4, 6, 7, 9, 10, and 12) and the total score for dysmotility-related symptoms (questions 2, 3, 5, 8, and 11) were compared. The number of patients in each group with a higher score for acid regurgitation symptoms (A>M), the same score for both symptoms (A = M), or a higher score for dysmotility symptoms (A<M) was examined. *Significant difference between asthma and COPD. #Significant difference between COPD and disease controls.
Fig. 3
Fig. 3
Mean score for each FFSG question in asthma (a), COPD (b), and disease control (c) patients with GERD. Asthma patients (n = 10), COPD patients (n = 13), and disease control patients were diagnosed as having GERD by the FSSG survey in each group. Vertical bars from 0 to 2 show the mean score for each question. *Significant difference between asthma and COPD. #Significant difference between COPD and disease controls.
Fig. 4
Fig. 4
The mean scores for questions 2 and question 7 in COPD or asthma patients with GERD having a history of disease exacerbation vs patients without having a history of exacerbation. The scores of COPD patients with GERD for question 2 (bloated stomach) (a). Scores are compared between COPD patients with GERD having a history vs without having a history of exacerbation. Scores of asthma patients with GERD for question 7 (unusual sensation of the throat) (b). Scores are compared between asthma patients with GERD having a history vs without having a history of exacerbation. *Significant difference between groups.
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