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. 2012 Winter;24(1):28-36.
doi: 10.1176/appi.neuropsych.11030060.

Mood response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Meghan C Campbell  1 , Kevin J Black, Patrick M Weaver, Heather M Lugar, Tom O Videen, Samer D Tabbal, Morvarid Karimi, Joel S Perlmutter, Tamara Hershey
Affiliations

Mood response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Meghan C Campbell et al. J Neuropsychiatry Clin Neurosci. 2012 Winter.

Abstract

Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) improves motor functioning but has variable effects on mood. Little is known about the relationship between electrode contact location and mood response. The authors identified the anatomical location of electrode contacts and measured mood response to stimulation with the Visual Analog Scale in 24 STN DBS PD patients. Participants reported greater positive mood and decreased anxiety and apathy with bilateral and unilateral stimulation. Left DBS improved mood more than right DBS. Right DBS-induced increase in positive mood was related to more medial and dorsal contact locations. These results highlight the functional heterogeneity of the STN.

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Conflict of interest statement

Dr. Karimi previously received partial fellowship funding from Medtronic, Inc., the manufacturer of the implanted stimulators; no other authors have any conflicts of interest related to this research.

Figures

Figure 1
Figure 1
Location and distribution of the clinically chosen optimal STN DBS electrode contacts superimposed on coronal slices from the Mai atlas . For illustration purposes, a 2 mm radius sphere was placed on the center of each active contact as a visual estimate of current spread . The scale bar indicates the number of points (participants) at that location.
Figure 2
Figure 2
Stimulation induced changes in mood response (mean ± SEM) for unilateral and bilateral DBS as compared to DBS OFF condition. * indicates a significant difference between left and right DBS-induced mood improvement (p<.05).
See this image and copyright information in PMC

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