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. 2013 Feb;37(2):296-302.
doi: 10.1038/ijo.2012.37. Epub 2012 Mar 27.

Body mass index across midlife and cognitive change in late life

A K Dahl  1 , L B Hassing, E I Fransson, M Gatz, C A Reynolds, N L Pedersen
Affiliations

Body mass index across midlife and cognitive change in late life

A K Dahl et al. Int J Obes (Lond). 2013 Feb.

Abstract

Background: High midlife body mass index (BMI) has been linked to a greater risk of dementia in late life, but few have studied the effect of BMI across midlife on cognitive abilities and cognitive change in a dementia-free sample.

Methods: We investigated the association between BMI, measured twice across midlife (mean age 40 and 61 years, respectively), and cognitive change in four domains across two decades in the Swedish Adoption/Twin Study of Aging.

Results: Latent growth curve models fitted to data from 657 non-demented participants showed that persons who were overweight/obese in early midlife had significantly lower cognitive performance across domains in late life and significantly steeper decline in perceptual speed, adjusting for cardio-metabolic factors. Both underweight and overweight/obesity in late midlife were associated with lower cognitive abilities in late life. However, the association between underweight and low cognitive abilities did not remain significant when weight decline between early and late midlife was controlled for.

Conclusion: There is a negative effect on cognitive abilities later in life related to being overweight/obese across midlife. Moreover, weight decline across midlife rather than low weight in late midlife per se was associated with low cognitive abilities. Weight patterns across midlife may be prodromal markers of late life cognitive health.

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Figures

Figure 1
Figure 1
Longitudinal Association between Early Midlife Body Mass Index and Cognitive Abilities in Late Life
See this image and copyright information in PMC

References

    1. Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A. Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study. Am J Clin Nutr. 2009;89(2):601–607. - PMC - PubMed
    1. Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadra S. Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study. Curr Alz Res. 2007;4:111–116. - PubMed
    1. Hassing LB, Dahl AK, Pedersen NL, Johansson B. Overweight in midlife is related to lower cognitive function 30 years later: a prospective study with longitudinal assessments. Dement Geriatr Cogn Disord. 2010;29(6):543–552. - PMC - PubMed
    1. Dahl A, Hassing LB, Fransson E, Berg S, Gatz M, Reynolds CA, et al. Being overweight in midlife is associated with lower cognitive ability and steeper cognitive decline in late life. J Gerontol A Biol Sci Med Sci. 2010;65(1):57–62. - PMC - PubMed
    1. Brubacher D, Monsch A, Stähelin H. Weight change and cognitive performance. Int J Obes. 2004;28:1163–1167. - PubMed

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