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. 2012 Jun;56(6):3432-4.
doi: 10.1128/AAC.00230-12. Epub 2012 Mar 26.

NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel

Corinne Arpin  1 , Patrick Noury, Delphine Boraud, Laure Coulange, Alain Manetti, Catherine André, Fatima M'Zali, Claudine Quentin
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NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel

Corinne Arpin et al. Antimicrob Agents Chemother. 2012 Jun.

Abstract

A carbapenem-resistant Klebsiella pneumoniae strain, Kp5196, was responsible for an uncomplicated cystitis in a patient living at home and without history of foreign travel. This isolate produced the metallocarbapenemase NDM-1 and was resistant to all antibiotics except tetracyclines and colistin. The K. pneumoniae strain belonged to sequence type ST15, and bla(NDM-1) was carried by a nontypeable conjugative plasmid. Two months later, a similar ST15 isolate, Kp5241, was present in the patient but was additionally colistin resistant.

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Figures

Fig 1
Fig 1
XbaI patterns of K. pneumoniae strains after pulsed-field gel electrophoresis analysis. Lanes 1 and 2, Kp5196 and Kp5241, respectively. Lane 3, Kp10197 (Belgian strain of ST15, NDM-1-producing K. pneumoniae) (3). Lane 4, K. pneumoniae ATCC 13883. Lanes 5 and 6, Kp5233 (OXA-48-producing K. pneumoniae, ST unknown), and Kp5069 (ST14 K. pneumoniae), respectively; two unrelated strains used as controls. Lanes M, lambda DNA ladder (Bio-Rad).
See this image and copyright information in PMC

References

    1. Arpin C, et al. 2012. Evolution of an incompatibility group IncA/C plasmid harboring blaCMY-16 and qnrA6 genes and its transfer through three clones of Providencia stuartii during a two year outbreak in a Tunisian burn unit. Antimicrob. Agents Chemother. 56:1342–1349 - PMC - PubMed
    1. Barton BM, Harding GP, Zuccarelli AJ. 1995. A general method for detecting and sizing large plasmids. Anal. Biochem. 226:235–240 - PubMed
    1. Bogaerts P, et al. 2011. Emergence of NDM-1-producing Enterobacteriaceae in Belgium. Antimicrob. Agents Chemother. 55:3036–3038 - PMC - PubMed
    1. Bogdanovich T, et al. 2011. Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258. Clin. Infect. Dis. 53:373–376 - PMC - PubMed
    1. Carattoli A, et al. 2005. Identification of plasmids by PCR-based replicon typing. J. Microbiol. Methods 63:219–228 - PubMed

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