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Review
. 2012 Mar 27:5:13.
doi: 10.1186/1756-8722-5-13.

The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer

Catherine Labbaye  1 , Ugo Testa
Affiliations
Review

The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer

Catherine Labbaye et al. J Hematol Oncol. .

Abstract

MicroRNA (miRs) represent a class of small non-coding regulatory RNAs playing a major role in the control of gene expression by repressing protein synthesis at the post-transcriptional level. Studies carried out during the last years have shown that some miRNAs plays a key role in the control of normal and malignant hgematopoiesis. In this review we focus on recent progress in analyzing the functional role of miR-146a in the control of normal and malignant hematopoiesis. On the other hand, this miRNA has shown to impact in the control of innate immune responses. Finally, many recent studies indicate a deregulation of miR-146 in many solid tumors and gene knockout studies indicate a role for this miRNA as a tumor suppressor.

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References

    1. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006;20:2202–2207. doi: 10.1101/gad.1444406. - DOI - PMC - PubMed
    1. Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 2006;103:12481–12486. doi: 10.1073/pnas.0605298103. - DOI - PMC - PubMed
    1. Hou J, Wang P, Liu L, Liu X, Ma F, An H, Wang Z, Cao X. MicroRNA-146a feedback inhibits RIG-1-dependent type I IFN production in macrophage by targeting TRAF6, IRAK1 and IRAK2. J Immunol. 2009;183:2150–2158. doi: 10.4049/jimmunol.0900707. - DOI - PubMed
    1. Perry MM, Maschos SA, Williams AE, Shapard NJ, Larner-Svensson H, Lindsay MA. Rapid changes in microRNA-146a expression negatively regulate the IL-1β-induced inflammatory response in human lung alveolar epithelial cells. J Immunol. 2008;180:5689–5698. - PMC - PubMed
    1. Rom S, Rom I, Passiatore G, Pacifici M, Radhakrishnan S, Del Valle L, Pina-Oveido S, Khalili K, Eletto D, Peruzzi F. CCL8/MCP-2 is a target for miR-146a in HIV1-infected human microglial cells. FASEB J. 2010;24:2292–2300. doi: 10.1096/fj.09-143503. - DOI - PMC - PubMed

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