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. 1990 Sep 24;528(1):170-4.
doi: 10.1016/0006-8993(90)90214-v.

Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease

D J Skene  1 , B Vivien-Roels, D L Sparks, J C Hunsaker, P Pévet, D Ravid, D F Swaab
Affiliations

Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease

D J Skene et al. Brain Res. .

Abstract

Melatonin and 5-methoxytryptophol (ML) were measured in human pineals (38 controls, 16 subjects with Alzheimer's disease). Time of death had a major influence on the indole concentrations with significantly higher melatonin levels occurring at night (22.00-10.00 h) and significantly higher ML levels occurring during the day (10.00-22.00 h). This daily variation disappeared in both the older subjects (55-92 years) and in the Alzheimer patients (55-89 years).

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